克瑞司那醇代谢物的微生物生产。
Microbial production of a crisnatol metabolite.
作者信息
Hufford C D, el-Sharkawy S H, Jurgens T M, Mikell J R
机构信息
Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.
出版信息
Pharm Res. 1992 May;9(5):623-5. doi: 10.1023/a:1015893808830.
PMID:1608892
Abstract
Microbial metabolism studies of crisnatol (1), a new DNA intercalator, has resulted in the isolation and characterization of a major metabolite identified as the C-1 hydroxylated crisnatol (2). The structure of the metabolite was established by comparison of its spectral data to that of crisnatol. Complete 13C-NMR assignments for crisnatol and its C-1 hydroxylated metabolite were also made.
摘要
对新型DNA嵌入剂克瑞那托（1）的微生物代谢研究，已导致一种主要代谢物的分离与表征，该代谢物被鉴定为C-1羟基化克瑞那托（2）。通过将其光谱数据与克瑞那托的光谱数据进行比较，确定了该代谢物的结构。还完成了克瑞那托及其C-1羟基化代谢物的全碳-核磁共振归属。
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