Microbial production of a crisnatol metabolite.
作者信息
Hufford C D, el-Sharkawy S H, Jurgens T M, Mikell J R
机构信息
Department of Pharmacognosy, School of Pharmacy, University of Mississippi, University 38677.
出版信息
Pharm Res. 1992 May;9(5):623-5. doi: 10.1023/a:1015893808830.
PMID:1608892
Abstract
Microbial metabolism studies of crisnatol (1), a new DNA intercalator, has resulted in the isolation and characterization of a major metabolite identified as the C-1 hydroxylated crisnatol (2). The structure of the metabolite was established by comparison of its spectral data to that of crisnatol. Complete 13C-NMR assignments for crisnatol and its C-1 hydroxylated metabolite were also made.
摘要
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