Martelli Alberto M, Follo Matilde Yung, Evangelisti Camilla, Falà Federica, Fiume Roberta, Billi Anna Maria, Cocco Lucio
Dipartimento di Scienze Anatomiche Umane e Fisiopatologia dell'Apparato Locomotore, Sezione di Anatomia Umana, Cell Signalling Laboratory, Università di Bologna, 40126 Bologna, Italy.
J Cell Biochem. 2005 Oct 1;96(2):285-92. doi: 10.1002/jcb.20527.
A distinct polyphosphoinositide cycle is present in the nucleus, and growing evidence suggests its importance in DNA replication, gene transcription, and apoptosis. Even though it was initially thought that nuclear inositol lipids would function as a source for second messengers, recent findings strongly indicate that lipids present in the nucleus also fulfil other roles. The scope of this review is to highlight the most intriguing advances made in the field over the last few years, such as the possibility that nuclear phosphatidylinositol (4,5) bisphosphate is involved in maintaining chromatin in a transcriptionally active conformation, the new emerging roles for intranuclear phosphatidylinositol (3,4,5) trisphosphate and phosphoinositide 3-kinase, and the evidence which suggests a tight relationship between a decreased level of nuclear phosphoinositide specific phospholipase C-beta1 and the evolution of myelodisplastic syndrome into acute myeloid leukemia.
细胞核中存在独特的多磷酸肌醇循环，越来越多的证据表明其在DNA复制、基因转录和细胞凋亡中具有重要作用。尽管最初认为核肌醇脂质可作为第二信使的来源，但最近的研究结果有力地表明，细胞核中的脂质还发挥着其他作用。本综述的范围是突出过去几年该领域取得的最引人入胜的进展，例如核磷脂酰肌醇（4,5）二磷酸参与维持染色质处于转录活性构象的可能性、核内磷脂酰肌醇（3,4,5）三磷酸和磷酸肌醇3激酶的新出现的作用，以及表明核磷酸肌醇特异性磷脂酶C-β1水平降低与骨髓增生异常综合征演变为急性髓系白血病之间存在紧密关系的证据。
