Zabawa Thomas P, Kasi Dhanalakshmi, Chemler Sherry R
Department of Chemistry, 618 Natural Sciences Complex, University at Buffalo, State University of New York, Buffalo, New York 14260, USA.
J Am Chem Soc. 2005 Aug 17;127(32):11250-1. doi: 10.1021/ja053335v.
A concise method for the synthesis of cyclic sulfamides and vicinal diamines is presented. This method is enabled by Cu(OAc)2 and demonstrates a new transformation for this metal. Both five- and six-membered vicinal diamine-containing heterocycles have been synthesized in good to excellent yields, and substrate-based asymmetric induction has been achieved. This is the first reported example of intramolecular diamination of olefins.
本文介绍了一种合成环状磺酰胺和邻二胺的简洁方法。该方法由醋酸铜（Cu(OAc)₂）实现，并展示了这种金属的一种新转化反应。含邻二胺的五元及六元杂环均已以良好至优异的产率合成出来，且实现了基于底物的不对称诱导。这是烯烃分子内双胺化反应的首例报道。
