Roose S P
College of Physicians and Surgeons, Columbia University, New York, NY.
Psychopharmacol Bull. 1992;28(1):35-43.
There has been a longstanding concern over the cardiovascular effects of antidepressant medication, originally prompted by the observation that patients who take overdoses of tricyclics most frequently die a cardiac death. This article (1) reviews the data on the cardiovascular effects of tricyclics, highlighting the methodological problems that plagued the early studies; (2) presents current techniques that are used in cardiovascular studies of psychotropic medication; and (3) discusses the problems of studying new nontricyclic drugs. Further, the article discusses some aspects of the complicated relationship between brain and heart function that are specifically relevant to whether there is inherent reason to believe that any drug that is effective as an antidepressant will necessarily affect cardiac function.
长期以来，人们一直关注抗抑郁药物对心血管系统的影响，最初是因为观察到过量服用三环类药物的患者最常死于心脏疾病。本文：（1）回顾了关于三环类药物心血管效应的数据，强调了早期研究中存在的方法学问题；（2）介绍了目前用于精神药物心血管研究的技术；（3）讨论了研究新型非三环类药物的问题。此外，本文还讨论了大脑与心脏功能之间复杂关系的一些方面，这些方面与是否有内在理由相信任何有效的抗抑郁药物必然会影响心脏功能特别相关。
