心血管毒性与三环类抗抑郁药
Cardiovascular toxicity and tricyclic antidepressants.
作者信息
Jackson W K, Roose S P, Glassman A H
机构信息
Department of Psychiatry, College of Physicians and Surgeons of Columbia University, New York, N.Y. 10032.
出版信息
Biomed Pharmacother. 1987;41(7):377-82.
This article reviews the cardiovascular effects of the standard tricyclic antidepressants and what is known of the cardiovascular effects of the newer antidepressants. The cardiovascular effects of the standard tricyclics are orthostatic hypotension, conduction delay and a potent antiarrhythmic effect. Patients who have congestive heart failure and are on cardiac medications are at greatly increased risk for orthostatic hypotension, while patients who have pre-existing conduction delay are at risk for heart block.
本文综述了标准三环类抗抑郁药的心血管效应以及已知的新型抗抑郁药的心血管效应。标准三环类药物的心血管效应包括体位性低血压、传导延迟和强效抗心律失常作用。患有充血性心力衰竭且正在服用心脏药物的患者发生体位性低血压的风险大大增加，而已有传导延迟的患者有发生心脏传导阻滞的风险。
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