从鼠到人的CD4+CD25+调节性T细胞。

CD4+CD25+-regulatory T cells from mouse to man.

作者信息

Wing K, Suri-Payer E, Rudin A

机构信息

Department of Rheumatology and Inflammation Research, Sahlgrenska Academy at Göteborg University, Göteborg, Sweden.

出版信息

Scand J Immunol. 2005 Jul;62(1):1-15. doi: 10.1111/j.1365-3083.2005.01634.x.

DOI:10.1111/j.1365-3083.2005.01634.x

PMID:16091121

Abstract

Immunological tolerance is one of the fundamental concepts of the immune system. During the past decade, CD4+CD25+-regulatory T cells have emerged as key players in the development of tolerance to autoantigens as well as to foreign antigens. Still many questions remain illusive regarding the basic properties of CD4+CD25+-regulatory T cells. This review aims to recapitulate some of the current understandings about the phenotype, function and clinical relevance of murine and human CD4+CD25+-regulatory T cells.

摘要

免疫耐受是免疫系统的基本概念之一。在过去十年中，CD4+CD25+调节性T细胞已成为对自身抗原以及外来抗原产生耐受的关键因素。然而，关于CD4+CD25+调节性T细胞的基本特性仍有许多问题尚不清楚。这篇综述旨在概括目前对小鼠和人类CD4+CD25+调节性T细胞的表型、功能及临床相关性的一些认识。