Mark E J, Shin D H
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston 02214.
Semin Diagn Pathol. 1992 May;9(2):110-6.
Individuals exposed to asbestos develop and die of bronchogenic carcinoma at rates well above individuals not exposed, but there is disagreement as to what factors other than the asbestos may be important in the histogenesis of the carcinoma. This report discusses the various theories as to how and why asbestos, cigarette smoke, asbestosis, and pleural disease may be involved in the development of the carcinoma. The authors conclude that other disease processes may mark individuals particularly likely to develop carcinoma of the lung, but that asbestos fibers have an independent role in the histogenesis of carcinoma of the lung.
接触石棉的个体患支气管源性癌并死于该病的几率远高于未接触者，但对于除石棉外哪些因素在该癌症的组织发生过程中可能起重要作用，仍存在分歧。本报告讨论了关于石棉、香烟烟雾、石棉肺和胸膜疾病如何以及为何可能参与该癌症发生发展的各种理论。作者得出结论，其他疾病过程可能标志着个体特别容易患肺癌，但石棉纤维在肺癌的组织发生过程中具有独立作用。
