Shin Hae-Won, Kang Suk Y, Sohn Young H
Department of Neurology and Brain Research Institute, Yonsei University College of Medicine, Seoul, Korea.
Mov Disord. 2005 Dec;20(12):1640-3. doi: 10.1002/mds.20642.
Various sensory symptoms and disturbed sensory perception are often observed in patients with idiopathic Parkinson's disease (PD). The basis of sensory disturbance in PD is unknown but possibly reflects a role for the basal ganglia in sensory processing. To investigate the relationship between the sensory dysfunction and dopaminergic deficiency in PD, we measured spatial discrimination using the Grating Orientation Task in 21 drug-naive patients with PD, before and after long-term antiparkinson therapy, and 25 age-matched healthy controls. The grating orientation threshold was significantly higher in patients (3.03 +/- 0.84) than controls (2.03 +/- 0.79). After 3 to 10 months of antiparkinson therapy, the grating orientation threshold was significantly lowered (2.66 +/- 0.84), although it was still higher than that in controls. Improvement in the patients' sensory function was significantly correlated with motor improvement (r = 0.44). These results suggest that sensory dysfunction in Parkinson's disease is related at least in part to the dopaminergic deficit.
在特发性帕金森病（PD）患者中经常观察到各种感觉症状和感觉障碍。PD中感觉障碍的基础尚不清楚，但可能反映了基底神经节在感觉处理中的作用。为了研究PD中感觉功能障碍与多巴胺能缺乏之间的关系，我们在21例未经药物治疗的PD患者长期抗帕金森治疗前后，以及25例年龄匹配的健康对照者中，使用光栅定向任务测量了空间辨别能力。患者的光栅定向阈值（3.03±0.84）显著高于对照组（2.03±0.79）。经过3至10个月的抗帕金森治疗后，光栅定向阈值显著降低（2.66±0.84），尽管仍高于对照组。患者感觉功能的改善与运动改善显著相关（r = 0.44）。这些结果表明，帕金森病中的感觉功能障碍至少部分与多巴胺能缺陷有关。
