University of Canterbury, Christchurch, New Zealand 8140.
J Clin Exp Neuropsychol. 2010 Feb;32(2):190-200. doi: 10.1080/13803390902902441. Epub 2009 May 29.
Visual-spatial disembedding requires a person to visually scan the stimulus and allocate spatial selective attention to the locations of relevant stimuli. Parkinson's disease (PD) is often associated with visual-spatial deficits, but the influence of PD on disembedding is not entirely known. The goal of this study is to learn whether participants with PD have defective visuospatial disembedding and whether this defect responds to dopaminergic treatment. We also wanted to examine the relationship of disembedding with other cognitive processes and the different parkinsonian clinical symptoms. Participants were PD patients and matched controls. PD participants were tested "on" and "off" medications on the Hidden Patterns Test (HPT) and tests of frontal-executive functions. PD patients had difficulties in visual-spatial disembedding that were not related to medication status, illness duration or severity, or symptom presentation, but were related to other tasks requiring visual scanning in response to alterations in spatial allocation of attention. Lack of improvement with dopaminergic treatment suggests deficits in other neurotransmitter-neuromodulatory systems or degenerative processes in the frontal-striatal networks, cortex, or basal ganglia.
视空间分离需要一个人对刺激进行视觉扫描，并将空间选择性注意分配到相关刺激的位置。帕金森病（PD）常与视空间缺陷有关，但 PD 对视空间分离的影响尚不完全清楚。本研究的目的是了解 PD 患者是否存在视觉空间分离缺陷，以及这种缺陷是否对多巴胺能治疗有反应。我们还想研究分离与其他认知过程以及不同的帕金森临床症状之间的关系。参与者为 PD 患者和匹配的对照组。PD 患者在接受 Hidden Patterns Test（HPT）和额叶执行功能测试时，接受了“开”和“关”药物治疗。PD 患者在视觉空间分离方面存在困难，这种困难与药物状态、疾病持续时间或严重程度或症状表现无关，而是与其他需要根据注意力空间分配的变化进行视觉扫描的任务有关。缺乏多巴胺能治疗的改善表明，在额叶-纹状体网络、皮层或基底神经节中存在其他神经递质-神经调质系统或退行性过程的缺陷。
