Dietrich P Y, Droz J P
Laboratoire d'hémato-immunologie, Inserm U333, Villejuif.
Rev Prat. 1992 May 15;42(10):1236-40.
Recently, there has been a significant increase in the knowledge about the molecular basis of renal cell carcinoma. Its sporadic form is characterized by a deletion on the short arm of chromosome 3, even for localized stages. The same genetic abnormality is found in renal cell carcinomas associated with the von Hippel-Lindau disease. Such findings strongly suggest the presence of a common tumor suppressor gene which seems involved in the genesis of sporadic renal cell carcinoma and in the predisposition of hereditary cancers. Other tumor suppressor genes located on other chromosomes, as well as over expression of growth factors, seem to be related to the progression of this malignancy. Further studies of the molecular events associated with cellular transformation should help to better understand the behavior of such cancers and to find new therapeutical approaches.
最近，关于肾细胞癌分子基础的知识有了显著增加。其散发性形式的特征是3号染色体短臂缺失，即使是局限性阶段也是如此。在与冯·希佩尔-林道病相关的肾细胞癌中也发现了相同的基因异常。这些发现强烈提示存在一种共同的肿瘤抑制基因，它似乎参与了散发性肾细胞癌的发生以及遗传性癌症的易感性。位于其他染色体上的其他肿瘤抑制基因，以及生长因子的过度表达，似乎与这种恶性肿瘤的进展有关。对与细胞转化相关的分子事件的进一步研究应有助于更好地理解此类癌症的行为，并找到新的治疗方法。
