从痤疮丙酸杆菌全基因组洞察其致病潜力

Insights in the pathogenic potential of Propionibacterium acnes from its complete genome.

作者信息

Brüggemann Holger

机构信息

Göttingen Genomics Laboratory, Institute of Microbiology and Genetics, University of Göttingen, Göttingen, Germany.

出版信息

Semin Cutan Med Surg. 2005 Jun;24(2):67-72. doi: 10.1016/j.sder.2005.03.001.

DOI:10.1016/j.sder.2005.03.001

PMID:16092793

Abstract

One of the long-lasting open questions in understanding acne is the role of the skin bacterium Propionibacterium acnes. Opinions within the scientific community diverge regarding the importance of this Gram-positive bacterium not only in acne but also in other P. acnes-associated diseases. The recently decoded genome gives us some clues with respect to its pathogenic potential and its strategies to survive in the harsh environment of human skin. This review focuses on the major findings of the genome sequence. Special attention has been drawn to the cell surface composition of P. acnes, its antigenic potential, and to enzymes that are potentially involved in degrading skin-derived substances.

摘要

在理解痤疮方面，长期存在的一个悬而未决的问题是皮肤细菌痤疮丙酸杆菌所起的作用。科学界对于这种革兰氏阳性菌的重要性看法不一，不仅在痤疮中如此，在其他与痤疮丙酸杆菌相关的疾病中也是如此。最近解码的基因组为我们提供了一些有关其致病潜力以及在人类皮肤恶劣环境中生存策略的线索。本综述聚焦于基因组序列的主要发现。特别关注了痤疮丙酸杆菌的细胞表面组成、其抗原潜力以及可能参与降解皮肤衍生物质的酶。