Bojar Richard A, Holland Keith T
University of Leeds, Skin Research Centre, Division of Microbiology, Department of Biochemistry and Molecular Biology, LeedsLS2 9JT, UK.
Clin Dermatol. 2004 Sep-Oct;22(5):375-9. doi: 10.1016/j.clindermatol.2004.03.005.
The involvement of microorganisms in the development of acne has a long and checkered history. Just over 100 years ago, Propionibacterium acnes (then known as Bacillus acnes) was isolated from acne lesions, and it was suggested that P. acnes was involved in the pathology of the disease. The 1960s saw the use of antibiotics to treat acne, and the consequent clinical success combined with reductions in P. acnes gave new impetus to the debate. Over the past two decades, the inevitable emergence of antibiotic-resistant strains of P. acnes as a consequence of acne therapy not only has reopened the debate as to the role of P. acnes in acne, but also has created some serious health care implications.
微生物在痤疮发病过程中的作用有着漫长而曲折的历史。就在100多年前，痤疮丙酸杆菌（当时称为痤疮芽孢杆菌）从痤疮皮损中分离出来，有人提出痤疮丙酸杆菌参与了该病的病理过程。20世纪60年代，抗生素被用于治疗痤疮，随之而来的临床成功以及痤疮丙酸杆菌数量的减少为这场争论注入了新的动力。在过去二十年里，由于痤疮治疗导致痤疮丙酸杆菌耐药菌株不可避免地出现，这不仅重新引发了关于痤疮丙酸杆菌在痤疮中作用的争论，还带来了一些严重的医疗问题。
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