Jann Jessica, Drevelle Olivier, Chen X Grant, Auclair-Gilbert Myriam, Soucy Gervais, Faucheux Nathalie, Fortier Louis-Charles
Department of Chemical and Biotechnological Engineering, Faculty of Engineering, Université de Sherbrooke 2500 boul. de l'Université Sherbrooke Québec J1K 2R1 Canada
Clinical Research Center of Centre Hospitalier Universitaire de Sherbrooke 12e Avenue N Sherbrooke Québec J1H 5N4 Canada.
RSC Adv. 2021 Nov 26;11(60):38172-38188. doi: 10.1039/d1ra07159a. eCollection 2021 Nov 23.
Infections caused by multidrug-resistant bacteria are a major public health problem. Their transmission is strongly linked to cross contamination inert surfaces, which can serve as reservoirs for pathogenic microorganisms. To address this problem, antibacterial materials applied to high-touch surfaces have been developed. However, reaching a rapid and lasting effectiveness under real life conditions of use remains challenging. In the present paper, hard-anodized aluminum (AA) materials impregnated with antibacterial agents (quaternary ammonium compounds (QACs) and/or nitrate silver (AgNO)) were prepared and characterized. The thickness of the anodized layer was about 50 μm with pore diameter of 70 nm. AA with QACs and/or AgNO had a water contact angle varying between 45 and 70°. The antibacterial activity of the materials was determined under different experimental settings to better mimic their use, and included liquid, humid, and dry conditions. AA-QAC surfaces demonstrated excellent efficiency, killing >99.9% of bacteria in 5 min on a wide range of Gram-positive (, , vancomycin-resistant ) and Gram-negative (streptomycin-resistant and encapsulated ) pathogens. AA-QACs showed a faster antibacterial activity (from 0.25 to 5 min) compared with antibacterial copper used as a reference (from 15 min to more than 1 h). We show that to maintain their high performance, AA-QACs should be used in low humidity environments and should be cleaned with solutions composed of QACs. Altogether, AA-QAC materials constitute promising candidates to prevent the transmission of pathogenic bacteria on high-touch surfaces.
多重耐药菌引起的感染是一个重大的公共卫生问题。它们的传播与惰性表面的交叉污染密切相关，这些表面可作为致病微生物的储存库。为了解决这个问题，已开发出应用于高接触表面的抗菌材料。然而，在实际使用条件下实现快速持久的有效性仍然具有挑战性。在本文中，制备并表征了浸渍有抗菌剂（季铵化合物（QACs）和/或硝酸银（AgNO））的硬质阳极氧化铝（AA）材料。阳极氧化层的厚度约为50μm，孔径为70nm。含有QACs和/或AgNO的AA的水接触角在45°至70°之间变化。在不同的实验设置下测定了材料的抗菌活性，以更好地模拟其使用情况，包括液体、潮湿和干燥条件。AA-QAC表面表现出优异的效率，在5分钟内对多种革兰氏阳性菌（ 、 、耐万古霉素 ）和革兰氏阴性菌（耐链霉素 和包膜 ）病原体的杀灭率>99.9%。与用作参考的抗菌铜（从15分钟到1小时以上）相比，AA-QACs显示出更快的抗菌活性（从0.25分钟到5分钟）。我们表明，为了保持其高性能，AA-QACs应在低湿度环境中使用，并用由QACs组成的溶液进行清洁。总之，AA-QAC材料是防止致病细菌在高接触表面传播的有前途的候选材料。
