Yu Chan-Mo, Youn Jinsuop, Lee Min-Kyoung
Department of Chemistry and Institute of Basic Sciences, Sungkyunkwan University, Suwon 440-746, Korea.
Org Lett. 2005 Aug 18;7(17):3733-6. doi: 10.1021/ol0513701.
A highly diastereoselective synthesis of 3 is achieved from the reaction of 1 with hexamethylditin catalyzed by palladium complex in the presence of 20 mol % tris(pentafluorophenyl)borane as a Lewis acid additive for a reversal of diastereoselectivity, whereas 2 is formed in the absence of Lewis acid additive. The method described herein is successful with various substrates 1 in good yields and high levels of diastereoselectivity. [reaction: see text]
通过1与六甲基二锡在钯配合物催化下反应，在20 mol%三（五氟苯基）硼烷作为路易斯酸添加剂存在下实现了3的高非对映选择性合成，该添加剂用于反转非对映选择性，而在没有路易斯酸添加剂的情况下生成2。本文所述方法适用于各种底物1，产率良好且非对映选择性高。[反应：见正文]
