Brunker Tim J, Anderson Brian J, Blank Natalia F, Glueck David S, Rheingold Arnold L
6128 Burke Laboratory, Department of Chemistry, Dartmouth College, Hanover, NH 03755, USA.
Org Lett. 2007 Mar 15;9(6):1109-12. doi: 10.1021/ol0700512. Epub 2007 Feb 14.
Enantioselective or diastereoselective intramolecular cyclization of functionalized secondary phosphines or their borane adducts catalyzed by chiral Pd(diphosphine) complexes gave P-stereogenic benzophospholanes in up to 70% ee. These results provide a new method for the synthesis of chiral phospholanes, which are valuable ligands in asymmetric catalysis. [reaction: see text]
手性钯（二膦）配合物催化的官能化仲膦或其硼烷加合物的对映选择性或非对映选择性分子内环化反应可得到对映体过量高达70％的P-立体异构苯并膦烷。这些结果为手性膦烷的合成提供了一种新方法，手性膦烷是不对称催化中有价值的配体。[反应：见正文]
