通过氮杂环卡宾介导的串联反应，由安息香或苯甲醛一步组装功能化γ-丁内酯。

One-step assembly of functionalized gamma-butyrolactones from benzoins or benzaldehydes via an N-heterocyclic carbene-mediated tandem reaction.

作者信息

Ye Wei, Cai Guanliang, Zhuang Zeyang, Jia Xueshun, Zhai Hongbin

机构信息

Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, China 200032.

出版信息

Org Lett. 2005 Aug 18;7(17):3769-71. doi: 10.1021/ol051422m.

DOI:10.1021/ol051422m

PMID:16092871

Abstract

We describe here a direct, efficient, one-step construction of gamma,gamma-difunctionalized gamma-butyrolactones from benzoins or benzaldehydes via a tandem reaction promoted by 1,3-dimethyl imidazolin-2-ylidene, an N-heterocyclic carbene (NHC). [reaction: see text]

摘要

我们在此描述了一种直接、高效的一步法，通过由1,3-二甲基咪唑啉-2-亚基（一种氮杂环卡宾（NHC））促进的串联反应，从安息香或苯甲醛构建γ,γ-双官能化γ-丁内酯。[反应：见正文]