Cohen Daniel T, Scheidt Karl A
Department of Chemistry, Center for Molecular Innovation and Drug Discovery, Chemistry of Life Processes Institute, Northwestern University, 2145 Sheridan Road, Evanston, IL, 60208, USA.
Chem Sci. 2012 Jan 1;3(1):53-57. doi: 10.1039/C1SC00621E.
Lewis acid activation with -heterocyclic carbene (NHC) catalysis has presented new opportunities for enantioselective reaction development. Recent findings illustrate that Lewis acids can play an important role in homoenolate annulations by: enhancement of the reactivity, reversal of the diastereo- or regioselectivity, and activation of previously inactive electrophiles. Additionally, the incorporation of a Lewis acid into Brønsted base-catalyzed conjugate addition allowed for an increase in yields.
用氮杂环卡宾（NHC）催化进行路易斯酸活化，为对映选择性反应的发展带来了新机遇。最近的研究结果表明，路易斯酸可通过以下方式在同烯醇化物环化反应中发挥重要作用：提高反应活性、反转非对映或区域选择性以及活化先前无活性的亲电试剂。此外，将路易斯酸引入布朗斯特碱催化的共轭加成反应中可提高产率。
