Cho Ilseung, Blaser Martin J, François Fritz, Mathew Jomol P, Ye Xiang Y, Goldberg Judith D, Bini Edmund J
Department of Medicine, New York University School of Medicine, New York, NY, USA.
Am J Epidemiol. 2005 Sep 15;162(6):579-84. doi: 10.1093/aje/kwi237. Epub 2005 Aug 10.
Obesity is an important public health problem in the United States. Because of its potential effects on gastric leptin homeostasis, Helicobacter pylori may play a role in regulating body weight. The authors' aim in this study was to examine the association between H. pylori colonization and overweight status. Nonpregnant participants in the Third National Health and Nutrition Examination Survey (1988-1994) aged > or = 20 years who had had H. pylori testing performed and body mass index (weight (kg)/height (m2)) measured were studied. Overweight was defined as a body mass index greater than or equal to 25. On the basis of serologic results, the participants were categorized into three H. pylori status groups: H. pylori-positive and cytotoxin-associated gene A (cagA)-positive (H. pylori+ cagA+), H. pylori-positive and cagA-negative (H. pylori+ cagA-), and H. pylori-negative (H. pylori-). Of the 7,003 subjects with complete body mass index and H. pylori data, 2,634 (weighted percentage, 22.9%) were H. pylori+ cagA+, 1,385 (15.1%) were H. pylori+ cagA-, and 2,984 (62.0%) were H. pylori-. The adjusted odds of being overweight were 1.17 (95% confidence interval: 0.98, 1.39; p = 0.075) for the H. pylori+ cagA+ group and 0.99 (95% confidence interval: 0.80, 1.22; p = 0.92) for the H. pylori+ cagA- group in comparison with H. pylori- subjects. Serum leptin levels did not differ significantly between the three H. pylori groups. In this US population-based study, there was no significant association between H. pylori colonization, cagA+ strains of H. pylori, and being overweight.
肥胖是美国一个重要的公共卫生问题。由于幽门螺杆菌可能对胃内瘦素稳态产生潜在影响，因此它可能在体重调节中发挥作用。作者在本研究中的目的是检验幽门螺杆菌定植与超重状态之间的关联。对参加第三次全国健康与营养检查调查（1988 - 1994年）、年龄≥20岁且接受过幽门螺杆菌检测并测量了体重指数（体重（千克）/身高（米²））的非孕妇参与者进行了研究。超重定义为体重指数大于或等于25。根据血清学结果，参与者被分为三个幽门螺杆菌状态组：幽门螺杆菌阳性且细胞毒素相关基因A（cagA）阳性（幽门螺杆菌+cagA+）、幽门螺杆菌阳性且cagA阴性（幽门螺杆菌+cagA-）以及幽门螺杆菌阴性（幽门螺杆菌-）。在7003名有完整体重指数和幽门螺杆菌数据的受试者中，2634名（加权百分比为22.9%）为幽门螺杆菌+cagA+，1385名（15.1%）为幽门螺杆菌+cagA-，2984名（62.0%）为幽门螺杆菌-。与幽门螺杆菌-受试者相比，幽门螺杆菌+cagA+组超重的校正比值比为1.17（95%置信区间：0.98，1.39；p = 0.075），幽门螺杆菌+cagA-组为0.99（95%置信区间：0.80，1.22；p = 0.92）。三个幽门螺杆菌组之间的血清瘦素水平没有显著差异。在这项基于美国人群的研究中，幽门螺杆菌定植、幽门螺杆菌cagA+菌株与超重之间没有显著关联。
