Kim Jong Wook, Baeg Myong Ki, Bang Chang Seok, Park Jong-Kyu, Oh Jung-Hwan
Division of Gastroenterology, Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Gyeonggi-do, Korea.
Division of Gastroenterology, Department of Internal Medicine, Catholic Kwandong University International St. Mary's Hospital, Incheon, Korea.
J Neurogastroenterol Motil. 2023 Jul 30;29(3):352-359. doi: 10.5056/jnm22179.
BACKGROUND/AIMS: There is growing interest in whether eradication (HPE) can affect body weight.
Data from 5 universities between January 2013 and December 2019 were analyzed retrospectively. -positive subjects who had body weight measurements taken at least twice at intervals of 3 months or longer were included. Using propensity score (PS)-matched data, changes in body mass index (BMI) and the lipid profile after HPE were compared with the non-HPE group.
Among 363 eligible patients, 131 HPE patients were PS-matched to 131 non-HPE patients. The median intervals between the measurements were 610 (range, 154-1250) days and 606 (range, 154-1648) days in the HPE and non-HPE groups, respectively. In both groups, the mean BMI increased (from 24.5 kg/m to 24.7 kg/m in the HPE group, and from 24.4 kg/m to 24.5 kg/m in the non-HPE group). The 2 groups did not show significantly different changes ( = 0.921). In the lowest baseline BMI quartile, the BMI increased after HPE by 1.23 (standard deviation [SD], 3.72) kg/m ( = 0.060), and the non-HPE group showed a decreased BMI at the time of follow-up (by -0.24 [SD, 5.25] kg/m; = 0.937) (between-group = 0.214). Triglyceride levels increased after HPE (mean: 135 [SD, 78] to 153 [SD, 100] mg/dL; between-group = 0.053).
The overall BMI change was not significantly different between the HPE and non-HPE groups, but patients with low BMI showed a tendency to gain weight after HPE. Triglyceride levels increased after HPE with marginal significance.
背景/目的：根除幽门螺杆菌（HPE）是否会影响体重受到越来越多的关注。
对2013年1月至2019年12月期间5所大学的数据进行回顾性分析。纳入了 -阳性且至少每隔3个月或更长时间测量两次体重的受试者。使用倾向评分（PS）匹配数据，将HPE后体重指数（BMI）和血脂谱的变化与非HPE组进行比较。
在363例符合条件的患者中，131例HPE患者与131例非HPE患者进行了PS匹配。HPE组和非HPE组测量之间的中位间隔分别为610（范围154 - 1250）天和606（范围154 - 1648）天。两组中，平均BMI均增加（HPE组从24.5kg/m²增至24.7kg/m²，非HPE组从24.4kg/m²增至24.5kg/m²）。两组变化无显著差异（P = 0.921）。在最低基线BMI四分位数中，HPE后BMI增加了1.23（标准差[SD]，3.72）kg/m²（P = 0.060），非HPE组在随访时BMI下降（-0.24[SD，5.25]kg/m²；P = 0.937）（组间P = 0.214）。HPE后甘油三酯水平升高（均值：135[SD，78]至153[SD，100]mg/dL；组间P = 0.053）。
HPE组和非HPE组总体BMI变化无显著差异，但BMI低的患者在HPE后有体重增加的趋势。HPE后甘油三酯水平升高，具有边缘显著性。
