Bjerknes Matthew, Cheng Hazel
Department of Medicine, Clinical Science Division, Medical Sciences Bldg., Univ. of Toronto, 1 King's College Circle, Toronto, Ontario, Canada M5S 1A8.
Am J Physiol Gastrointest Liver Physiol. 2005 Sep;289(3):G381-7. doi: 10.1152/ajpgi.00160.2005.
Current views of the identity, distribution, and regulation of small intestinal epithelial stem cells and their immediate progeny are discussed. Recent works implicating Wnt signaling in stem and progenitor proliferation, the involvement of Notch signaling in epithelial lineage specification, and the role of hedgehog and bone morphogenetic protein families in crypt formation are integrated. We had the good fortune that many of these papers came in pairs from independent groups. We attempt to identify points of agreement, reinterpret each in the context of the other, and indicate directions for continued progress.
本文讨论了目前关于小肠上皮干细胞及其直接子代细胞的身份、分布和调控的观点。近期的研究表明，Wnt信号传导参与干细胞和祖细胞的增殖，Notch信号传导参与上皮细胞谱系的分化，而刺猬信号通路和骨形态发生蛋白家族在隐窝形成中发挥作用。幸运的是，许多相关论文是由独立研究小组成对发表的。我们试图找出这些研究中的共识点，在相互关联的背景下重新解读每一项研究，并指出后续研究的方向。
