Desset S, Vaury Ch
INSERM U384, Faculté de Médecine, Clermont-Ferrand, France.
Cytogenet Genome Res. 2005;110(1-4):209-14. doi: 10.1159/000084954.
Systematic sequencing of model genomes has accelerated our knowledge on genome structure and shown that a large proportion of intergenic regions are made up of mobile element families. Among them, retrotransposons that are mobilized via an RNA intermediate and thus do not excise during their replication cycle are certainly essential factors able to imprint novel and heritable transcriptional regulation within the genome of their host. Today, a crucial complement to the systematic sequencing data is thus to elucidate the potential role of these elements in the regulation of nearby genes, and ultimately in the evolution of eukaryotic genomes.
对模式生物基因组进行系统测序加速了我们对基因组结构的了解，并表明很大一部分基因间区域由移动元件家族组成。其中，通过RNA中间体进行移动因而在复制周期中不会切除的逆转录转座子无疑是能够在其宿主基因组内施加新的可遗传转录调控的关键因素。因此，如今对系统测序数据的一个关键补充是阐明这些元件在附近基因调控中，乃至最终在真核生物基因组进化中的潜在作用。
