苦味对胃动力的影响。

Impact of bitter taste on gastric motility.

作者信息

Wicks David, Wright Jeff, Rayment Pip, Spiller Robin

机构信息

School of Medical and Surgical Sciences, University of Nottingham, Nottingham, UK.

出版信息

Eur J Gastroenterol Hepatol. 2005 Sep;17(9):961-5. doi: 10.1097/00042737-200509000-00012.

DOI:10.1097/00042737-200509000-00012

PMID:16093874

Abstract

BACKGROUND

Unexplained nausea and vomiting is often associated with delayed gastric emptying in patients with functional dyspepsia. We hypothesized that the experience of an unpleasant, nauseating taste could lead to a delay in gastric emptying.

METHODS

Sixteen healthy women consumed a bland liquid test meal on three separate study days. On two of the study days subjects sham fed either a bitter tasting, modified Slim-Fast bar or one with a pleasant strawberry flavour. The time for 50% gastric emptying (GE(50)) was non-invasively assessed by electrical impedance tomography and antral motility by electrogastrography (EGG).

RESULTS

Gastric emptying was significantly delayed by sham feeding the bitter compared with the pleasant bar, GE(50) 24.7+/-3.9 versus 17.2+/-1.8 min, P<0.05. EGG power rose significantly during both the pleasant (basal 1.46+/-0.07 to 2.33+/-0.14 log(10) microV(2)/min, P=0.000) and the bitter sham feed (basal 1.64+/-0.09 to 2.35+/-0.11 log(10) microV(2)/min, P=0.000).

CONCLUSION

An unpleasant bitter taste delays gastric emptying but does not significantly impair antral motility.

摘要

背景

不明原因的恶心和呕吐常与功能性消化不良患者的胃排空延迟有关。我们推测，不愉快的、令人作呕的味道体验可能会导致胃排空延迟。

方法

16名健康女性在三个不同的研究日食用了清淡的液体试验餐。在其中两个研究日，受试者假进食苦味的改良速食棒或有宜人草莓味的速食棒。通过电阻抗断层扫描非侵入性评估50%胃排空时间（GE(50)），通过胃电图（EGG）评估胃窦运动。

结果

与食用宜人味道的速食棒相比，假进食苦味速食棒使胃排空显著延迟，GE(50)分别为24.7±3.9分钟和17.2±1.8分钟，P<0.05。在食用宜人味道速食棒（基础值1.46±0.07至2.33±0.14 log(10)微伏²/分钟，P=0.000）和苦味速食棒假进食期间（基础值1.64±0.09至2.35±0.11 log(10)微伏²/分钟，P=0.000），EGG功率均显著升高。