Bennink R, Peeters M, Van den Maegdenbergh V, Geypens B, Rutgeerts P, De Roo M, Mortelmans L
Department of Nuclear Medicine, UZ KU Leuven, Herestraat 49, B-3000 Leuven, Belgium.
Eur J Nucl Med. 1998 Sep;25(9):1293-9. doi: 10.1007/s002590050298.
There is increasing evidence of gender-related differences in gastric emptying. The purpose of this study was first, to confirm the difference in gastric emptying for both solid and liquid test meals between healthy men and women, and secondly, to investigate the origin of this difference by studying regional gastric emptying and antral motility. A standard gastric emptying test with additional compartmental (proximal and distal) evaluation and dynamic imaging of the antrum was performed in 20 healthy women studied during the first 10 days of the menstrual cycle, and in 31 healthy age-matched men. In concordance with previous reports, women had a longer half-emptying time for solids as compared to men (86. 2+/-5.1 vs 52.2+/-2.9 min, P<0.05). In our observations this seemed to be related to a significantly prolonged lag phase and a significant decrease in terminal slope. Dynamical antral scintigraphy did not show a significant difference. The distribution of the test meal within the stomach (proximal vs distal) showed more early proximal retention in women as compared to men. The terminal slope of the distal stomach was significantly lower in women. We did not observe a significant difference in gastric emptying of the liquid test meal between men and women. Gastric emptying of solids is significantly slower in healthy women as compared to men. These findings emphasise the importance of using different normal values for clinical and research purposes in gastric emptying scintigraphy in men and women. The difference could not be explained by antral motility alone. Increased proximal retention and a lower terminal emptying rate in women are observations to be further investigated.
越来越多的证据表明胃排空存在与性别相关的差异。本研究的目的，其一，是确认健康男性和女性在固体和液体测试餐胃排空方面的差异；其二，通过研究胃排空区域和胃窦蠕动来探究这种差异的根源。对20名在月经周期前10天接受研究的健康女性和31名年龄匹配的健康男性进行了一项标准胃排空测试，并对胃窦进行了额外的分区（近端和远端）评估及动态成像。与先前的报告一致，与男性相比，女性固体食物的半排空时间更长（86.2±5.1分钟对52.2±2.9分钟，P<0.05）。在我们的观察中，这似乎与显著延长的延迟期和终末斜率的显著降低有关。动态胃窦闪烁扫描未显示出显著差异。与男性相比，女性测试餐在胃内的分布（近端与远端）显示出更多早期近端潴留。女性远端胃的终末斜率显著更低。我们未观察到男性和女性在液体测试餐胃排空方面存在显著差异。与男性相比，健康女性固体食物的胃排空明显更慢。这些发现强调了在男性和女性的胃排空闪烁扫描中，出于临床和研究目的使用不同正常值的重要性。这种差异不能仅由胃窦蠕动来解释。女性近端潴留增加和终末排空率降低是有待进一步研究的观察结果。
