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保留附睾的双侧单纯睾丸切除术联合附睾成形术:保留美观和身体形象。

Epididymal sparing bilateral simple orchiectomy with epididymoplasty: preservation of esthetics and body image.

作者信息

Issa Muta M, Lendvay Thomas S, Bouet Rafael, Young Mark R, Petros John A, Marshall Fray F

机构信息

Department of Urology, Emory University School of Medicine, Atlanta Veterans Affairs Medical Center, Decatur, Georgia 30033, USA.

出版信息

J Urol. 2005 Sep;174(3):893-7. doi: 10.1097/01.ju.0000172567.09442.b0.

Abstract

PURPOSE

We report the surgical technique and results of epididymal sparing bilateral simple orchiectomy as an esthetic alternative to standard bilateral simple orchiectomy and luteinizing hormone releasing hormone (LH-RH) agonist injection therapy in patients with prostate cancer.

MATERIALS AND METHODS

The study included 91 consecutive epididymal sparing bilateral simple orchiectomy (BSO) procedures that were performed at the Atlanta Veterans Affairs Medical Center during a 25-month period. All patients had pathologically confirmed prostate cancer. A total of 52 patients (57.1%) were receiving LH-RH agonist therapy prior to the procedure and the remaining 39 (42.9%) were not. All procedures were performed in an outpatient clinic setting using spermatic cord anesthesia block as the only method of anesthesia. In the 52 patients who were on LH-RH agonist therapy prior to the procedure the overall impression/satisfaction with the procedure was evaluated using a questionnaire.

RESULTS

All 91 procedures were performed at the urology outpatient clinic using local anesthesia. Mean patient age was 74.2 years (range 44 to 86). Mean serum prostate specific antigen was 58.9 ng/ml. The mean time required to perform the spermatic cord anesthesia block was 3.9 minutes (range 2 to 6) and the volume of anesthetic solution was 18.9 ml per case (range 10 to 32). Despite significant difference in testicular size between patients receiving and not receiving LH/RH agonists there were no differences in anesthesia time or anesthetic volume (3.9 and 3.9 minutes, p = 0.97, and 18.6 and 19.4 ml, respectively, p = 0.47). Mean operative time for BSO excluding anesthesia time was 36.9 minutes (range 18 to 70). Mean operative time was similar in patients receiving and not receiving LH-RH agonists (36.2 and 37.8 minutes, respectively, p = 0.39). The procedure was well tolerated, as judged by the mean intraoperative pain score during BSO of 0.2 (range 0 to 3). The majority of patients (76 or 83.5%) were pain-free during the procedure. Pain scores were similar in patients who were and were not receiving LH-RH agonists during BSO (p = 0.97). There were no adverse events. Followup data were available on 26 of the 52 patients who were receiving LH-RH agonist therapy prior to the procedure. Of them 96.2% were satisfied with the results and 84.6% preferred the procedure over medical castration therapy with LH-RH agonist therapy.

CONCLUSIONS

Epididymal sparing bilateral simple orchiectomy is a simple and safe procedure that can be conveniently performed in an outpatient clinic setting using pure local anesthesia. Preservation of the epididymis and subsequent epididymoplasty is effective for maintaining the esthetic appearance of the scrotum and patient satisfaction. The procedure offers patients the convenience of 1-time surgical therapy over lifelong medical injection therapy at a significantly lower cost and without significantly compromising the esthetic appearance of the scrotum.

摘要

目的

我们报告保留附睾的双侧单纯睾丸切除术的手术技术及结果,该手术可作为前列腺癌患者标准双侧单纯睾丸切除术及黄体生成素释放激素(LH-RH)激动剂注射治疗的一种美观替代方案。

材料与方法

本研究纳入了在亚特兰大退伍军人事务医疗中心25个月期间连续进行的91例保留附睾的双侧单纯睾丸切除术(BSO)。所有患者均经病理确诊为前列腺癌。共有52例患者(57.1%)在手术前接受LH-RH激动剂治疗,其余39例(42.9%)未接受。所有手术均在门诊进行,采用精索麻醉阻滞作为唯一麻醉方法。对52例术前接受LH-RH激动剂治疗的患者,使用问卷评估其对手术的总体印象/满意度。

结果

所有91例手术均在泌尿外科门诊采用局部麻醉进行。患者平均年龄为74.2岁(范围44至86岁)。血清前列腺特异性抗原平均为58.9 ng/ml。进行精索麻醉阻滞的平均时间为3.9分钟(范围2至6分钟),每例麻醉溶液体积为18.9 ml(范围10至32 ml)。尽管接受和未接受LH/RH激动剂的患者睾丸大小存在显著差异,但麻醉时间或麻醉体积无差异(分别为3.9分钟和3.9分钟,p = 0.97;18.6 ml和19.4 ml,p = 0.47)。排除麻醉时间后,BSO的平均手术时间为36.9分钟(范围18至70分钟)。接受和未接受LH-RH激动剂的患者平均手术时间相似(分别为36.分钟和37.8分钟,p = 0.39)。根据BSO期间术中平均疼痛评分为0.2(范围0至3)判断,该手术耐受性良好。大多数患者(76例或83.5%)在手术过程中无疼痛。BSO期间接受和未接受LH-RH激动剂的患者疼痛评分相似(p = 0.97)。无不良事件发生。术前接受LH-RH激动剂治疗的52例患者中有26例有随访数据。其中96.2%对结果满意,84.6%比LH-RH激动剂药物去势治疗更喜欢该手术。

结论

保留附睾的双侧单纯睾丸切除术是一种简单安全的手术,可在门诊采用单纯局部麻醉方便地进行。保留附睾及随后的附睾成形术对于维持阴囊的美观外观和患者满意度是有效的。该手术为患者提供了一次性手术治疗的便利,相较于终身药物注射治疗,成本显著降低,且不显著影响阴囊的美观外观。

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