Roostaeian Jason, Suh Jeffrey D, Sercarz Joel A, Abemayor Elliot, Lee Jivianne T, Blackwell Keith E
Division of Head and Neck Surgery, the Department of Surgery, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA 90095-1624, U.S.A.
Laryngoscope. 2005 Aug;115(8):1391-4. doi: 10.1097/01.MLG.0000166706.61652.15.
Our objective was to determine which factors are associated with cancer recurrence after microvascular reconstruction of the head and neck for squamous cell carcinoma (SCC).
A cohort of patients who fit the inclusion/exclusion criteria were identified retrospectively.
A group of 184 patients who underwent successful surgical resection and simultaneous microvascular reconstruction of the head and neck for treatment of SCC were identified. The mean age was 60 (range 23-90) years, there were 115 males and 69 females, and mean follow-up was 26.2 (range 1-99) months. Various factors were analyzed to determine whether they were associated with cancer recurrence, including those pertaining to 1) recipient vessel choice, 2) prior cancer treatment, and 3) cancer staging criteria. Statistical analysis was performed using SPSS statistical software.
Overall cancer stage (P = .005), T stage (P = .0001), history of previous cancer treatment (P = .004), and history of previous chemotherapy (P = .044) were found to be statistically significant predictors of cancer recurrence on univariate analysis. However, on multivariate analysis, only T stage (P = .005) and history of previous cancer treatment (P = .008) remained as statistically significant predictors of cancer recurrence. Recipient vessel selection was not statistically associated with cancer recurrence.
In our study, only T stage and a history of previous cancer treatment were associated with increased cancer recurrence. Neither the recipient vessel chosen nor its location impacted cancer recurrence. This suggests that recipient vessel selection and preparation for microvascular reconstruction do not jeopardize the adequacy of oncologic resection and are therefore oncologically sound.
我们的目的是确定哪些因素与头颈部鳞状细胞癌（SCC）微血管重建术后的癌症复发相关。
回顾性确定符合纳入/排除标准的一组患者。
确定了一组184例因SCC接受成功手术切除并同时进行头颈部微血管重建的患者。平均年龄为60岁（范围23 - 90岁），男性115例，女性69例，平均随访时间为26.2个月（范围1 - 99个月）。分析了各种因素以确定它们是否与癌症复发相关，包括与以下方面有关的因素：1）受体血管选择；2）既往癌症治疗情况；3）癌症分期标准。使用SPSS统计软件进行统计分析。
在单因素分析中，总体癌症分期（P = .005）、T分期（P = .0001）、既往癌症治疗史（P = .004）和既往化疗史（P = .044）被发现是癌症复发的统计学显著预测因素。然而，在多因素分析中，只有T分期（P = .005）和既往癌症治疗史（P = .008）仍然是癌症复发的统计学显著预测因素。受体血管选择与癌症复发无统计学关联。
在我们的研究中，只有T分期和既往癌症治疗史与癌症复发增加相关。所选择的受体血管及其位置均未影响癌症复发。这表明受体血管选择和微血管重建准备不会损害肿瘤切除的充分性，因此在肿瘤学上是合理的。
