Department of Plastic Surgery, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University and College of Medicine, No. 123, Ta-Pei Road, Niao-Song District, Kaohsiung City, 83301, Taiwan.
Sci Rep. 2021 Jan 27;11(1):2350. doi: 10.1038/s41598-021-82034-5.
This study was designed to compare the outcome and analyze the operation-related risk factors in free flap reconstruction for patients with primary and recurrent head and neck cancers. A 1:1 propensity score-matched analysis of the microsurgery registry database of the hospital. The primary outcome of the free flap reconstruction had a higher failure rate in the recurrent group than the primary group (5.1% vs. 3.1%, p = 0.037). Among the 345 pairs in the matched study population, there were no significant differences between the primary and recurrent groups regarding the rate of total flap loss (3.5% vs. 5.5%, p = 0.27) and secondary outcomes. This study revealed that free flap reconstruction had a higher failure rate in the recurrent group than the primary group, but such a difference may be attributed by the different patient characteristics.
本研究旨在比较原发性和复发性头颈部癌症患者游离皮瓣重建的结果，并分析与手术相关的风险因素。对医院的显微外科注册数据库进行了 1:1 的倾向评分匹配分析。游离皮瓣重建的主要结果显示，复发组的失败率高于初治组（5.1%比 3.1%，p=0.037）。在匹配的研究人群中的 345 对中，原发性和复发性组之间在总皮瓣丧失率（3.5%比 5.5%，p=0.27）和次要结果方面无显著差异。本研究表明，游离皮瓣重建在复发性组中的失败率高于初治组，但这种差异可能归因于不同的患者特征。
