Fitzpatrick K A, Sinclair D A, Schulze S R, Syrzycka M, Honda B M
Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, Canada.
Genome. 2005 Aug;48(4):571-84. doi: 10.1139/g05-025.
In this review, we combine the results of our published and unpublished work with the published results of other laboratories to provide an updated map of the centromeric heterochromatin of chromosome 3 in Drosophila melanogaster. To date, we can identify more than 20 genes (defined DNA sequences with well-characterized functions and (or) defined genetic complementation groups), including at least 16 essential loci. With the ongoing emergence of data from genetic, cytological, and genome sequencing studies, we anticipate continued, substantial progress towards understanding the function, structure, and evolution of centric heterochromatin.
在本综述中，我们将已发表和未发表的研究结果与其他实验室已发表的结果相结合，以提供黑腹果蝇3号染色体着丝粒异染色质的最新图谱。迄今为止，我们能够鉴定出20多个基因（具有明确功能和（或）明确遗传互补群的特定DNA序列），包括至少16个必需位点。随着遗传、细胞学和基因组测序研究数据的不断涌现，我们预计在理解着丝粒异染色质的功能、结构和进化方面将持续取得重大进展。
