Muegge Kathrin
Laboratory of Cancer Prevention, National Cancer Institute, Frederick, MD 21701, USA.
Biochem Cell Biol. 2005 Aug;83(4):548-54. doi: 10.1139/o05-119.
Lymphoid-specific helicase (Lsh) is a crucial factor for normal embryonic development; targeted deletion of Lsh is lethal. Lsh belongs to a family of chromatin-remodeling proteins and is closely associated with pericentromeric heterochromatin. Lsh deficiency leads to abnormal heterochromatin organization, with a loss of DNA methylation, and an altered pattern of histone-tail acetylation and methylation. As a functional consequence of perturbed heterochromatin, aberrant reactivation of parasitic retroviral elements in the genome and abnormal mitosis with amplified centrosomes and genomic instability were observed. Thus, Lsh is a major epigenetic regulator crucial for normal heterochromatin structure and function.
淋巴特异性解旋酶（Lsh）是正常胚胎发育的关键因素；Lsh的靶向缺失是致死性的。Lsh属于染色质重塑蛋白家族，与着丝粒周围异染色质密切相关。Lsh缺乏会导致异染色质组织异常，DNA甲基化缺失，以及组蛋白尾部乙酰化和甲基化模式改变。作为异染色质紊乱的功能后果，观察到基因组中寄生逆转录病毒元件的异常激活以及中心体扩增和基因组不稳定的异常有丝分裂。因此，Lsh是正常异染色质结构和功能的主要表观遗传调节因子。
