Rooney Kathleen A, Nutsch Robert G, Skogerboe Terry L, Weigel Daniel J, Gajewski Kimberly, Kilgore W Randal
Pfizer Animal Health, Veterinary Medicine Research and Development, Kalamazoo, MI 49001, USA.
Vet Ther. 2005 Summer;6(2):154-66.
Three studies conducted at feedlots in Colorado, Idaho, and Texas examined the comparative efficacy of tulathromycin injectable solution for the treatment of cattle at high risk of developing undifferentiated bovine respiratory disease (BRD). Each study randomly allocated 250 calves to receive tulathromycin at 2.5 mg/kg and 250 calves to receive either tilmicosin at 10 mg/kg (Colorado site) or florfenicol at 40 mg/kg (Idaho and Texas sites) on arrival at the feedlot. Calves were housed by treatment group in pens with 50 calves/pen. Beginning 3 days after antimicrobial treatment, cattle were observed for signs of BRD daily until harvest. In all three studies, the treatment success rates at 28 days after treatment and at harvest were significantly higher (P < or = .013) for cattle treated with tulathromycin than for cattle treated with either tilmicosin or florfenicol. Fewer tulathromycin-treated cattle were removed from the group as "chronics" or "mortalities" at 28 days posttreatment (P < or = .014) in all three studies. Tulathromycin demonstrated superior efficacy compared with tilmicosin and florfenicol when treating groups of high-risk cattle before the onset of signs of BRD.
在科罗拉多州、爱达荷州和得克萨斯州的饲养场进行的三项研究，检验了泰拉霉素注射液对处于发生未分化型牛呼吸道疾病（BRD）高风险的牛的治疗效果。每项研究随机分配250头犊牛，在到达饲养场时，250头犊牛接受2.5毫克/千克的泰拉霉素治疗，另外250头犊牛接受10毫克/千克的替米考星治疗（科罗拉多州试验点）或40毫克/千克的氟苯尼考治疗（爱达荷州和得克萨斯州试验点）。犊牛按治疗组饲养在栏舍中，每栏50头犊牛。在抗菌治疗开始3天后，每天观察牛群是否有BRD症状，直至出栏。在所有三项研究中，接受泰拉霉素治疗的牛在治疗后28天和出栏时的治疗成功率，显著高于接受替米考星或氟苯尼考治疗的牛（P≤0.013）。在所有三项研究中，接受泰拉霉素治疗的牛在治疗后28天作为“慢性病牛”或“死亡牛”被移出组群的数量较少（P≤0.014）。在BRD症状出现之前治疗高风险牛群时，泰拉霉素的疗效优于替米考星和氟苯尼考。
