Nanjiani Ian A, McKelvie Jo, Benchaoui Hafid A, Godinho Kevin S, Sherington John, Sunderland Simon J, Weatherley Andrew J, Rowan Tim G
Veterinary Medicine Research and Development, Pfizer Ltd, Sandwich, Kent, UK.
Vet Ther. 2005 Summer;6(2):203-13.
The clinical efficacy of tulathromycin in the treatment of natural outbreaks of swine respiratory disease (SRD) was evaluated at five European sites. Pigs (1 to 6 months of age) exhibiting clinical signs of SRD were treated intramuscularly with tulathromycin (n = 247) at 2.5 mg/kg on day 0 versus either tiamulin (n = 102) at 15 mg/kg on days 0, 1, and 2 (Germany, the Netherlands, and the United Kingdom) or florfenicol (n = 20) at 15 mg/kg on days 0 and 2 (France). Actinobacillus pleuropneumoniae, Pasteurella multocida, and Mycoplasma hyopneumoniae infections were the most frequently diagnosed pathogens. For both tulathromycin-treated animals and those treated with tiamulin or florfenicol, there were significant (P = .0001) reductions in mean rectal temperature and the severity of abnormal clinical signs on days 2 and 10 compared with day 0. There were no significant differences (P > .05) between treatments in average daily weight gain. Tulathromycin was found to be safe and highly effective in the treatment of natural outbreaks of SRD.
在欧洲的五个地点评估了图拉霉素治疗猪呼吸道疾病（SRD）自然爆发的临床疗效。对表现出SRD临床症状的猪（1至6月龄），在第0天以2.5mg/kg的剂量肌肉注射图拉霉素（n = 247），与之对比的是，在德国、荷兰和英国，于第0、1和2天以15mg/kg的剂量肌肉注射泰妙菌素（n = 102）；在法国，于第0和2天以15mg/kg的剂量肌肉注射氟苯尼考（n = 20）。胸膜肺炎放线杆菌、多杀性巴氏杆菌和猪肺炎支原体感染是最常诊断出的病原体。与第0天相比，在第2天和第10天，接受图拉霉素治疗的动物以及接受泰妙菌素或氟苯尼考治疗的动物，平均直肠温度和异常临床症状的严重程度均显著降低（P = .0001）。各治疗组之间的平均日增重无显著差异（P > .05）。结果发现，图拉霉素在治疗SRD自然爆发方面安全且高效。
