Liu Caibing, Gu Yingchun, Qian Zhiyong, Fan Linyu, Li Jun, Chao Guotao, Tu Mingjing, Jia Wenjuan
College of Material Science and Engineering, Sichuan University, Chengdu, 610065, People's Republic of China.
J Biomed Mater Res A. 2005 Nov 1;75(2):465-71. doi: 10.1002/jbm.a.30453.
In this article, a new kind of biodegradable polyetheresteramide-based polyurethane (PEEA-U) copolymers were prepared by the melt polycondensation method from epsilon-caprolactone, 6-aminocaproic acid, poly(ethylene glycol), and toluene diisocyanate. The water absorption of PEEA-U was affected strongly by the reaction time and the content of chain extender; and the hydrolytic degradation behavior of the copolymers was mainly determined by the reaction time, chain extender content, and the pH value of the degradation medium. Also, DSC, (1)H-NMR, and inherent viscosity were used to characterize the degradation behavior of the copolymers.
在本文中，通过熔融缩聚法，以ε-己内酯、6-氨基己酸、聚乙二醇和甲苯二异氰酸酯为原料制备了一种新型的可生物降解的聚醚酯酰胺基聚氨酯（PEEA-U）共聚物。PEEA-U的吸水率受反应时间和扩链剂含量的强烈影响；共聚物的水解降解行为主要由反应时间、扩链剂含量和降解介质的pH值决定。此外，差示扫描量热法（DSC）、核磁共振氢谱（¹H-NMR）和特性粘度被用于表征共聚物的降解行为。
