20年间中国结直肠癌发病模式的变化
Changing patterns of colorectal cancer in China over a period of 20 years.
作者信息
Li Ming, Gu Jin
机构信息
Department of Surgery, Beijing Cancer Hospital, Peking University School of Oncology, China.
出版信息
World J Gastroenterol. 2005 Aug 14;11(30):4685-8. doi: 10.3748/wjg.v11.i30.4685.
AIM
To determine whether any changes have occurred on the patterns of colorectal cancer in China.
METHODS
Data from 21 Chinese articles published from 1980 to 1999, were used to analyze the time trend of colorectal cancer according to the patients' age at diagnosis, sex, the site of the tumor, stage, and the pathology.
RESULTS
From 1980s to 1990s, the mean age of the colorectal cancer patients has increased. The percentage of the female patients rose. The distribution of colorectal carcinoma shows a predominance of rectal cancer. However, the proportion of proximal colon cancer (including transverse and ascending colon) increased significantly accompanied by a decline in the percentage of rectal cancer. Similarity in the percentage of distal colon cancer between two decades was revealed. In the 1990s, statistically more Stage B patients were found than those in 1980s. In addition, databases show a significant decrease in the Stage D cases. The proportion of adenocarcinoma increased, but the mucinous adenocarcinoma decreased during two decades.
CONCLUSION
These findings indicate that the pattern of colorectal cancer in China has been changing. Especially, a proximal shift due to the increasing proportion of ascending and transverse colon cancer has occurred in China.
目的
确定中国结直肠癌的发病模式是否发生了任何变化。
方法
使用1980年至1999年发表的21篇中文文章中的数据，根据诊断时患者的年龄、性别、肿瘤部位、分期和病理来分析结直肠癌的时间趋势。
结果
从20世纪80年代到90年代，结直肠癌患者的平均年龄有所增加。女性患者的比例上升。结直肠癌的分布显示直肠癌占主导地位。然而，近端结肠癌（包括横结肠和升结肠）的比例显著增加，同时直肠癌的比例下降。两个十年间远端结肠癌的比例相似。在20世纪90年代，统计发现B期患者比20世纪80年代更多。此外，数据库显示D期病例显著减少。腺癌的比例增加，但黏液腺癌在两个十年间减少。
结论
这些发现表明中国结直肠癌的发病模式一直在变化。特别是，由于升结肠和横结肠癌比例的增加，中国出现了近端转移。
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