Zhang Wenwen, Zou Ying, Zhao Feng, Yang Yongqing, Mao Ning, Li Yuan, Huang Gang, Yao Zhijun, Hu Bin
Department of Radiology, Gansu Provincial Hospital, Lanzhou, China.
Department of Information Engineering, Yantai Vocational College, Yantai, China.
Front Neurol. 2022 Jun 29;13:791298. doi: 10.3389/fneur.2022.791298. eCollection 2022.
Surgery and chemotherapy may increase depression tendency in patients with rectal cancer (RC). Nevertheless, few comprehensive studies are conducted on alterations of brain network induced by depression tendency in patients with RC. Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) data were collected from 42 patients with RC with surgery and chemotherapy and 38 healthy controls (HCs). Functional network (FN) was constructed from extracting average time courses in brain regions, and structural network (SN) was established by deterministic tractography. Graph theoretical analysis was used to calculate network properties. Networks resilient of two networks were assessed. Clinical correlation analysis was explored between altered network parameters and Hamilton depression scale (HAMD) score. This study revealed impaired FN and SN at both local and global levels and changed nodal efficiency and abnormal small-worldness property in patients with RC. On the whole, all FNs are more robust than SN. Moreover, compared with HC, patients with RC show less robustness in both networks. Regions with decreased nodal efficiency were associated with HAMD score. These cognitive dysfunctions are mainly attributable to depression-related brain functional and structural network alterations. Brain network reorganization is to prevent patients with RC from more serious depression after surgery and chemotherapy.
手术和化疗可能会增加直肠癌（RC）患者的抑郁倾向。然而，针对RC患者抑郁倾向所引发的脑网络改变，开展的全面研究较少。我们收集了42例接受手术和化疗的RC患者以及38名健康对照者（HCs）的静息态功能磁共振成像（rs-fMRI）和扩散张量成像（DTI）数据。通过提取脑区的平均时间序列构建功能网络（FN），并通过确定性纤维束成像建立结构网络（SN）。采用图论分析来计算网络属性。评估两个网络的弹性。探讨改变的网络参数与汉密尔顿抑郁量表（HAMD）评分之间的临床相关性分析。本研究揭示了RC患者在局部和整体水平上FN和SN受损，以及节点效率改变和小世界属性异常。总体而言，所有FN比SN更具鲁棒性。此外，与HC相比，RC患者在两个网络中的鲁棒性均较低。节点效率降低的区域与HAMD评分相关。这些认知功能障碍主要归因于与抑郁相关的脑功能和结构网络改变。脑网络重组旨在防止RC患者在手术和化疗后出现更严重的抑郁。
