Koh Kai Shing, Telisinghe Pemasari Upali, Bickle Ian, Abdullah Muhammad Syafiq, Chong Chee Fui, Chong Vui Heng
Department of Surgery, RIPAS Hospital, Brunei Darussalam E-mail :
Asian Pac J Cancer Prev. 2015;16(8):3279-83. doi: 10.7314/apjcp.2015.16.8.3279.
Colorectal cancer (CRC) is the most common gastrointestinal cancer and the incidence is increasing. CRC is more common with increasing age, but a proportion occurs in young adults, termed young CRC. This study assessed the incidence and the demographic of young CRC in Brunei Darussalam.
All histologically proven CRC between 1986 and 2014 registered with the Department of Pathology cancer registry were reviewed and data extracted for analyses. Young CRC was defined as cancer in patients aged less than 45 years. The various population groups were categorized into locals (Malays, Chinese and Indigenous) and expatriates.
Over the study period, there were 1,126 histologically proven CRC (mean age 59.1 ± 14.7 years, Male 58.0%, Locals 91.8% and 8.2% expatriates). Young CRC accounted for 15.1% with the proportion declining over the years, from 29% (1986-1990) to 13.2% (2011-2014). The proportion of young CRC was highest among the indigenous (30.8%), followed by the expatriates (29.3%), Malays (14.3%) and lowest among the Chinese (10.8%). The mean age of young CRC was 35.9 ± 6.2; lowest among the indigenous (33.5 ± 6.7), expatriate (34.9 ± 6.0) groupd and the Malays (35.6 ± 6.5) compared to the Chinese (38.6 ± 4.6), a similar trend being observed in the non-young CRC groups. There were no difference between the genders and tumor locations (rectum or colon) between the young and the non-young CRC cases. Female young CRC was significantly younger than male (p<0.05) without any significant variation between the various population groups (p>0.05).
Our study showed that the young CRC accounted for 15.1% of all CRC with declining trend observed over recent years. Young CRC was more common among indigenous, expatriates and Malays and least common among the Chinese. There were no differences in the gender and tumor locations.
结直肠癌（CRC）是最常见的胃肠道癌症，且发病率呈上升趋势。CRC在老年人中更为常见，但仍有一定比例发生在年轻人中，称为青年结直肠癌。本研究评估了文莱达鲁萨兰国青年结直肠癌的发病率和人口统计学特征。
回顾了1986年至2014年在病理科癌症登记处登记的所有经组织学证实的结直肠癌病例，并提取数据进行分析。青年结直肠癌定义为年龄小于45岁患者所患的癌症。不同人群分为本地人（马来人、华人及原住民）和外籍人士。
在研究期间，共有1126例经组织学证实的结直肠癌患者（平均年龄59.1±14.7岁，男性占58.0%，本地人占91.8%，外籍人士占8.2%）。青年结直肠癌占15.1%，且该比例多年来呈下降趋势，从1986 - 1990年的29%降至2011 - 2014年的13.2%。青年结直肠癌比例在原住民中最高（30.8%），其次是外籍人士（29.3%）、马来人（14.3%），在华人中最低（10.8%）。青年结直肠癌的平均年龄为35.9±6.2岁；在原住民（33.5±6.7岁）、外籍人士（34.9±6.0岁）和马来人（35.6±6.5岁）中最低，而华人（38.6±4.6岁）相对较高，在非青年结直肠癌组中也观察到类似趋势。青年和非青年结直肠癌病例在性别和肿瘤部位（直肠或结肠）方面无差异。女性青年结直肠癌患者明显比男性年轻（p<0.05），不同人群之间无显著差异（p>0.05）。
我们的研究表明，青年结直肠癌占所有结直肠癌的15.1%，近年来呈下降趋势。青年结直肠癌在原住民、外籍人士和马来人中更为常见，在华人中最不常见。在性别和肿瘤部位方面无差异。
