一种新型凋亡抑制因子——生存素在结直肠癌中的表达
Expression of a novel apoptosis inhibitor-survivin in colorectal carcinoma.
作者信息
Tan Hai-Yan, Liu Jun, Wu Shan-Min, Luo He-Sheng
机构信息
Department of General Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, China.
出版信息
World J Gastroenterol. 2005 Aug 14;11(30):4689-92. doi: 10.3748/wjg.v11.i30.4689.
AIM
To investigate the role of survivin expression in the pathogenesis of colorectal carcinoma.
METHODS
Immunohistochemistry S-P method and terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) were used to detect the expression of survivin and apoptotic cell in situ in colorectal cancerous tissues, para-cancerous tissues and normal tissues of 48 cases of colorectal carcinoma.
RESULTS
The survivin positive unit (PU) was higher in cancerous tissues (38.76+/-5.14) than in para-cancerous (25.17+/-7.26) or normal tissues (0.57+/-0.03) (P<0.05). The apoptosis index (AI) of para-cancerous tissues was (7.51+/-2.63%) higher than cancerous tissues (4.65+/-1.76%). The expression of survivin was associated with pathological grade, lymph node metastasis and Dukes stage of colorectal carcinoma.
CONCLUSION
Survivin expression may play an important role in carcinogenesis of colorectal carcinoma and may be associated with malignant biological behaviors of colorectal carcinoma.
目的
探讨生存素表达在结直肠癌发病机制中的作用。
方法
采用免疫组织化学S-P法及末端脱氧核苷酸转移酶介导的dUTP缺口末端标记法（TUNEL）检测48例结直肠癌患者癌组织、癌旁组织及正常组织中生存素的表达及原位凋亡细胞。
结果
癌组织中生存素阳性单位（PU）为（38.76±5.14），高于癌旁组织（25.17±7.26）及正常组织（0.57±0.03）（P<0.05）。癌旁组织凋亡指数（AI）为（7.51±2.63%），高于癌组织（4.65±1.76%）。生存素表达与结直肠癌的病理分级、淋巴结转移及Dukes分期有关。
结论
生存素表达可能在结直肠癌发生中起重要作用，且可能与结直肠癌的恶性生物学行为有关。
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