Nakhla H B, Mohammed O S, Abu al Futuh I M, Adam S E
Faculty of Pharmacy, University of Khartoum, Sudan.
Vet Hum Toxicol. 1992 Jun;34(3):224-6.
The effect of oral or parenteral administration of crude saponin extract from Balanites aegyptiaca seed kernal on Hisex-type chicks was studied. Seven-d-old chicks were given 5 mg Balanites crude saponin/kg/d im, 25 mg/kg/d ip or 250 mg/kg/day po for 3 w. When compared to controls, the body weights of dosed chicks were depressed and serum LDH and GOT activities and uric acid concentrations were significantly elevated. There were no consistent differences in serum GGT, CPK, total cholesterol and total protein between control and dosed birds. The main lesions were fatty cytoplasmic vacuolation and necrosis of hepatocytes, lymphocytic nodules, epithelial cell degeneration of the renal tubules, catarrhal enteritis and varying degrees of hemorrhage in the thigh and breast muscles. Myositis or peritonitis were observed in chicks given Balanites crude saponins im or ip, respectively.
研究了口服或肠胃外给予埃及 balanites 种子仁粗皂苷提取物对海赛克斯型雏鸡的影响。7 日龄雏鸡连续 3 周每天分别按 5 毫克巴拉尼蒂斯粗皂苷/千克体重进行肌肉注射、25 毫克/千克体重进行腹腔注射或 250 毫克/千克体重进行口服给药。与对照组相比，给药雏鸡的体重下降，血清乳酸脱氢酶（LDH）、谷草转氨酶（GOT）活性及尿酸浓度显著升高。对照组和给药组鸡的血清γ-谷氨酰转肽酶（GGT）、肌酸磷酸激酶（CPK）、总胆固醇和总蛋白无一致差异。主要病变为肝细胞脂肪性细胞质空泡化和坏死、淋巴细胞结节、肾小管上皮细胞变性、卡他性肠炎以及大腿和胸肌不同程度的出血。分别在肌肉注射或腹腔注射巴拉尼蒂斯粗皂苷的雏鸡中观察到了肌炎或腹膜炎。
