Ratomski Karol, Wysocka Jolanta, Hassmann-Poznańska Elzbieta, Kasprzycka Edwina
Zakład Laboratoryjnej Diagnostyki Pediatrycznej AM w Białymstoku.
Otolaryngol Pol. 2005;59(2):219-23.
Tonsil pharyngeal is stimulated chronic by pathogens can be causes this hypertrophied; whose often is companions to otitis media with effusion. Subpopulation dominates in tonsil pharyngeal are lymphocytes B, and their markers activation are expression of antigen CD23+. The aim of this study was finding dependence between otitis media with effusion and coexistent hypertrophy adenoids, and percentage of lymphocytes CD19+ with expression of antigen CD23+ in hypertrophy adenoids. In the study showed higher significant percentage of lymphocytes CD19+ CD23+ at children in otitis media with effusion (20.08+/-2.93) with reference to comparative group, which was only hypertrophy adenoid (18.16+/-2.25). Percentage lymphocytes B (CD23+) were the highest (20.01+/-5.81) in children subgroup above 5 years old with otitis media with effusion, and lowest (17.36+/-2.78) in children comparative subgroup above 5 years old. As regards on different functions of antigen CD23+ the assessment of percentage lymphocytes B with expression of CD23+ can be additional marker in course immunological and inflammatory processes to occur in hypertrophy adenoids at children are sick otitis media with effusion.
咽扁桃体受到病原体的慢性刺激可导致其肥大；其常与分泌性中耳炎相伴。在咽扁桃体中占主导地位的亚群是B淋巴细胞，其活化标志物是抗原CD23+的表达。本研究的目的是发现分泌性中耳炎与并存的腺样体肥大之间的相关性，以及腺样体肥大中CD19+淋巴细胞与抗原CD23+表达的百分比之间的关系。研究表明，与仅腺样体肥大的对照组相比，分泌性中耳炎患儿中CD19+ CD23+淋巴细胞的百分比显著更高（20.08±2.93）。5岁以上分泌性中耳炎患儿亚组中B淋巴细胞（CD23+）的百分比最高（20.01±5.81），5岁以上对照亚组中最低（17.36±2.78）。关于抗原CD23+的不同功能，评估表达CD23+ 的B淋巴细胞百分比可作为患有分泌性中耳炎患儿腺样体肥大中发生的免疫和炎症过程的附加标志物。
