丝裂霉素C诱导的肾功能损害中的肾小球簇气球样变。

Glomerular tuft ballooning in mitomycin-C-induced renal impairment.

作者信息

Shiiki H, Dohi K, Nishioka H, Matsuda T, Kanauchi M, Uyama H, Ishikawa H, Watanabe T

机构信息

First Department of Internal Medicine, Nara Medical University, Japan.

出版信息

Virchows Arch A Pathol Anat Histopathol. 1992;420(6):545-51. doi: 10.1007/BF01600261.

DOI:10.1007/BF01600261

PMID:1609513

Abstract

Severe ballooning of the glomerular tufts was observed in a 65-year-old man who was treated with mitomycin C (MMC) and had typical MMC-induced renal lesions. He developed renal failure and severe anaemia 6 months after initiation of chemotherapy. Ballooned tufts were caused by enormous expansion of the sub-endothelial space simultaneously associated with mesangiolysis. Glomerular cysts, described in a variety of disorders including thrombotic microangiopathy and diabetes mellitus, are derived from cystically dilated and united capillary luminae secondary to mesangiolysis. The morphogenesis of this unusual lesion when induced by MMC differs from that of the glomerular cysts previously reported.

摘要

在一名接受丝裂霉素C（MMC）治疗且有典型MMC诱导的肾损伤的65岁男性中，观察到肾小球簇严重气球样变。化疗开始6个月后，他出现肾衰竭和严重贫血。气球样变的簇是由内皮下间隙的巨大扩张同时伴有系膜溶解引起的。肾小球囊肿见于包括血栓性微血管病和糖尿病在内的多种疾病，它源自系膜溶解继发的囊性扩张和融合的毛细血管腔。MMC诱导时这种不寻常病变的形态发生与先前报道的肾小球囊肿不同。