Hamner R W, Verani R, Weinman E J
Arch Intern Med. 1983 Apr;143(4):803-7.
Renal failure due to mitomycin chemotherapy is a poorly appreciated entity often associated with microangiopathic hemolytic anemia. We describe a 45-year-old man in whom renal failure and anemia developed, without evidence of hemolysis, five months after beginning chemotherapy with mitomycin, fluorouracil, and doxorubicin hydrochloride. A biopsy specimen taken from the patient's kidney showed fibrin thrombi in two of 18 glomeruli and in several small arteries. The patient's condition required institution of maintenance dialysis. Similar reports from the literature are reviewed.
丝裂霉素化疗所致肾衰竭是一种鲜为人知的病症，常与微血管病性溶血性贫血相关。我们描述了一名45岁男性，他在开始使用丝裂霉素、氟尿嘧啶和盐酸多柔比星化疗五个月后出现肾衰竭和贫血，但无溶血证据。取自该患者肾脏的活检标本显示，18个肾小球中有2个以及几条小动脉中有纤维蛋白血栓。患者的病情需要进行维持性透析。本文对文献中的类似报道进行了综述。
