Johns Imogen, Stephen Jennifer O, Del Piero Fabio, Richardson Dean W, Wilkins Pamela A
University of Pennsylvania, George D. Widener Hospital, New Bolton Center, Kennett Square, PA 19348, USA.
J Vet Intern Med. 2005 Jul-Aug;19(4):564-70. doi: 10.1892/0891-6640(2005)19[564:hiyh]2.0.co;2.
Hemangiosarcoma is a rare neoplasm of horses and hemangiosarcoma in young horses might behave differently than in mature horses. The purpose of this study was to identify the characteristics of hemangiosarcoma occurring in horses < or = 3 years of age. Medical records from 1982 to 2004 were searched for horses < or = 3 years of age with a histopathologic diagnosis of hemangiosarcoma. Eleven records were identified. Thoroughbred and Thoroughbred crosses predominated. Age ranged from 9 days to 3 years. All horses presented with cutaneous or leg swellings or joint effusion. Physical examination findings included tachycardia, fever, and depression. Laboratory abnormalities included anemia (5/11), hyperfibrinogenemia (4/11), hypofibrinogenemia (3/11), thrombocytopenia (2/11), and neutrophilic leukocytosis (1/11). Ultrasonographic and radiographic evaluation was not diagnostic in any case. Antemortem histopathologic diagnosis was obtained in 10 cases. Six of 11 horses were euthanized. Surgical resection was performed in 5 horses, 2 of which were later euthanized. Diagnosis was confirmed histologically at postmortem examination in all euthanized horses. Two cases resolved spontaneously. Early histopathologic diagnosis may allow cure if the mass is localized and amenable to surgical resection. In cases where the horse is medically stable, and masses are not interfering with quality of life, a period of observation may be warranted.
血管肉瘤是马的一种罕见肿瘤,幼年马的血管肉瘤表现可能与成年马不同。本研究的目的是确定3岁及以下马发生的血管肉瘤的特征。检索了1982年至2004年的医疗记录,查找3岁及以下经组织病理学诊断为血管肉瘤的马。共确定了11份记录。纯种马和纯种杂交马占主导。年龄范围从9天至3岁。所有马匹均表现为皮肤或腿部肿胀或关节积液。体格检查结果包括心动过速、发热和精神沉郁。实验室异常包括贫血(5/11)、高纤维蛋白原血症(4/11)、低纤维蛋白原血症(3/11)、血小板减少(2/11)和嗜中性白细胞增多(1/11)。超声和放射学评估在任何病例中均未确诊。10例获得了生前组织病理学诊断。11匹马中有6匹实施了安乐死。5匹马进行了手术切除,其中2匹后来实施了安乐死。所有实施安乐死的马匹在死后检查时经组织学确诊。2例自行缓解。如果肿块局限且适合手术切除,早期组织病理学诊断可能实现治愈。在马匹病情稳定且肿块不影响生活质量的情况下,可能有必要进行一段时间的观察。