Sohn C, Stolz W, Gast A S, Bastert G
Universitätsfrauenklinik Heidelberg.
Z Geburtshilfe Perinatol. 1992 Mar-Apr;196(2):55-60.
Until now, it has been possible to determine fetal pulmonary maturity only by amniocentesis. Since the functional changes of the fetal lung leading to maturity are also morphologically apparent, pulmonary maturity can be demonstrated sonographically. Obtaining a uniform value for maturity is a problem, since the position of the fetus, the mother's constitution and the instrument setting all influence assessment. The fetal liver was therefore used as a reference organ, since it is subject to the same influences. By frequency analysis of both organs and calculation of the ratio between the frequencies obtained, a mathematical value can be calculated by which pregnancies can be compared and which, as our studies showed, represents a measure of pulmonary maturity. This was documented in 348 patients. It was shown by amniocentesis in 32 patients and the postpartal condition of 25 premature births that a value of 1.11 for this ratio between lung and liver represents the borderline between pulmonary immaturity and maturity. Lower values indicate maturity. If these results are confirmed by further studies on larger groups of patients, it will in future be possible to determine fetal pulmonary maturity very easily and non-invasively.
到目前为止，只能通过羊膜穿刺术来确定胎儿肺成熟度。由于导致胎儿肺成熟的功能变化在形态上也很明显，因此可以通过超声检查来显示肺成熟度。获得一个统一的成熟度数值是个问题，因为胎儿的位置、母亲的体质以及仪器设置都会影响评估。因此，胎儿肝脏被用作参考器官，因为它也受到同样的影响。通过对两个器官进行频率分析并计算所获得频率之间的比率，可以计算出一个数学值，通过这个值可以对妊娠进行比较，而且正如我们的研究所表明的，它代表了肺成熟度的一个指标。这在348名患者中得到了证实。通过羊膜穿刺术对32名患者以及25例早产产后情况的研究表明，肺与肝的这个比率为1.11代表肺未成熟与成熟之间的界限。较低的值表明成熟。如果这些结果在对更多患者群体的进一步研究中得到证实，那么将来就有可能非常容易且无创地确定胎儿肺成熟度。
