Sohn C, Stolz W, Bastert G, von Fournier D
Abteilung Allgemeine Frauenheilkunde und Geburtshilfe mit Poliklinik, Universitäts-Frauenklinik Heidelberg.
Zentralbl Gynakol. 1992;114(5):238-43.
First results are presented to determine the maturity of fetal lung by sonography. Using the fetal liver as a reference-organ we are avoiding the known pitfalls which made it impossible in the past to standardize the fetal lung changes depending on the age of gestation. We examined 104 patients between week 27 and week 41. In one ultrasound section cut we depicted as well lung and liver. According to the known A-mode we registered frequencies in both organs. The registered frequencies were entered digitally into a computer and checked for f(mean), f(max) and f(min). Afterwards the frequencies of the lung were divided by those of the liver. Of all weeks of gestation the mean value and standard deviation were calculated. We found the liver as an adequate reference-organ, since there is no change of the reflection pattern between the different weeks of gestation, while there are significant changes to be registered in the fetal lung, a cutting line being week 35. A quotient of f(mean) lower than 1.1 hints to lung maturity while values over 1.1 point to immaturity. This was confirmed by several cases of analysis of amniotic fluid (L/S-ratio). Further comparisons with amniotic fluid results will have to validate these findings.
首次展示了通过超声检查来确定胎儿肺成熟度的结果。以胎儿肝脏作为参照器官，我们避免了以往那些导致无法根据孕周来标准化胎儿肺部变化的已知缺陷。我们检查了27至41周之间的104名患者。在一个超声切面中同时描绘出肺和肝脏。根据已知的A超模式，我们记录了两个器官的频率。记录的频率被数字输入计算机，并检查f（均值）、f（最大值）和f（最小值）。之后，将肺的频率除以肝脏的频率。计算出所有孕周的平均值和标准差。我们发现肝脏是一个合适的参照器官，因为在不同孕周之间其反射模式没有变化，而胎儿肺则有显著变化，分界线为35周。f（均值）的商低于1.1提示肺成熟，而高于1.1则表明不成熟。这在几例羊水分析（L/S比值）中得到了证实。与羊水结果的进一步比较将验证这些发现。
