Sedelmeier Jörg, Bolm Carsten
Institute of Organic Chemistry, RWTH-Aachen University, Landoltweg 1, D-52056 Aachen, Germany.
J Org Chem. 2005 Aug 19;70(17):6904-6. doi: 10.1021/jo051066l.
Two simple and inexpensive systems for copper-catalyzed N-arylations of sulfoximines with aryl bromides and aryl iodides have been developed. Using 10 mol % of a copper(I) salt in combination with 20 mol % of a 1,2-diamine and Cs2CO3 provides N-arylated sulfoximines in high yields. Various functional groups and heteroatoms are tolerated. The method is complementary to the known protocols for N-arylations of sulfoximines, which require stoichiometric quantities of copper salts or cost-intensive palladium/BINAP catalysts.
已开发出两种用于铜催化亚砜亚胺与芳基溴化物和芳基碘化物进行N-芳基化反应的简单且廉价的体系。使用10 mol%的铜(I)盐与20 mol%的1,2-二胺和碳酸铯组合，可高产率地得到N-芳基化亚砜亚胺。该方法能耐受各种官能团和杂原子。此方法是对已知的亚砜亚胺N-芳基化方案的补充，后者需要化学计量的铜盐或成本高昂的钯/联萘酚催化剂。
