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[曲马多联合或不联合止吐药及哌替啶用于产科镇痛的有效性及耐受性]

[Effectiveness and tolerance of tramadol with or without an antiemetic and pethidine in obstetric analgesia].

作者信息

Kainz C, Joura E, Obwegeser R, Plöckinger B, Gruber W

机构信息

II. Universitäts-Frauenklinik Wien.

出版信息

Z Geburtshilfe Perinatol. 1992 Mar-Apr;196(2):78-82.

PMID:1609533
Abstract

The aim of this prospective, randomised, blind study was to investigate the analgesic potency and tolerance of intramuscular Tramadol compared to a standard obstetric analgesia with Pethidine. Triflupromazine was administrated in combination with the two tested analgesics in order to study its efficacy in alleviating the emetic side effects of the tested analgesics. 66 parturients were randomly assigned to three groups: group A: 100 mg Tramadol (Tramal), group B: 100 mg Tramadol (Tramal) and 10 mg Triflupromazine (Psyquil), group C: 50 mg Pethidine (Alodan) and 10 mg Triflupromazine (Psyquil). No significant differences concerning duration of labour, FHR-alterations, umbilical cord blood gases, respiration pattern and Apgar Scores of the neonate occurred. In all three groups the analgesic effect was equally good. Combination of the analgesic with the antiemetic showed no reduction of the incidence and severity of side effects.

摘要

这项前瞻性、随机、盲法研究的目的是,对比肌肉注射曲马多与标准产科哌替啶镇痛的镇痛效力及耐受性。将三氟拉嗪与两种受试镇痛药联合使用,以研究其缓解受试镇痛药呕吐副作用的疗效。66名产妇被随机分为三组:A组:100毫克曲马多(曲马朵);B组:100毫克曲马多(曲马朵)加10毫克三氟拉嗪(甲哌氯丙嗪);C组:50毫克哌替啶(阿洛丁)加10毫克三氟拉嗪(甲哌氯丙嗪)。在产程时长、胎心率变化、脐血气、呼吸模式及新生儿阿普加评分方面未出现显著差异。在所有三组中,镇痛效果同样良好。镇痛药与止吐药联合使用并未降低副作用的发生率及严重程度。

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