Bredow V
Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe, Medizinischen Fakultät, Ernst-Moritz-Arndt-Universität Greifswald.
Zentralbl Gynakol. 1992;114(11):551-4.
Because tramadol does not exhibit an depressive effect on ventilatory activity it is often be used in the obstetrical analgesia, at most in form of an intramuscularly injection. In a prospective study on at all 49 women under labour the clinical effect of the noninvasive rectal application of Tramadol, Pethidin, and Denaverin has been compared. The first dosage was 100 mg of all substances. Around the half of the women said that analgetic effect was good or very good. On only every fifth it was sufficient or not enough. The effect was at near the same in all treatment groups. Because of a low incidence of maternal side effects, the absence of side effects on the newborn, and near the same results on the analgetic effect of parenteral application in other studies, tramadol suppositories can be recommended for obstetrical analgesia.
由于曲马多对呼吸活动无抑制作用,它常被用于产科镇痛,最多采用肌肉注射的形式。在一项针对49名分娩期妇女的前瞻性研究中,比较了曲马多、哌替啶和地那韦林经直肠无创给药的临床效果。所有药物的首次剂量均为100毫克。约一半的妇女表示镇痛效果良好或非常好。只有五分之一的妇女认为效果足够或不够。所有治疗组的效果几乎相同。由于母体副作用发生率低,对新生儿无副作用,且在其他研究中肠外给药的镇痛效果相近,因此曲马多栓剂可推荐用于产科镇痛。