Edwards J J, Soto R G, Bedford R F
Department of Anesthesiology, University of South Florida College of Medicine, Tampa and the All Children's Hospital, St. Petersburg, FL, USA.
Acta Anaesthesiol Scand. 2005 Sep;49(8):1084-7. doi: 10.1111/j.1399-6576.2005.00813.x.
Previously, we have shown in adult patients that bispectral index score (BIS) values are significantly higher during halothane anesthesia (53-61 units) as compared with those observed during equipotent concentrations of sevoflurane (39-43 units). Because halothane is frequently used in the pediatric setting, we tested the hypothesis that BIS values observed in children might also be higher during general anesthesia with halothane than with sevoflurane.
Forty-one healthy, unpremedicated pediatric patients scheduled for elective operations received either halothane or sevoflurane titrated as appropriate for surgical stimulation.
During maintenance sevoflurane anesthesia (n=20), the mean BIS values and percent end-tidal concentrations were 44+/-14 and 2.1+/-0.6, respectively, whereas for the halothane group (n=21) the corresponding values were 61+/-7 and 1.1+/-0.4, respectively.
These findings suggest that BIS values are higher during halothane vs. sevoflurane anesthesia in children, but not in infants.
此前，我们已在成年患者中发现，与等效浓度的七氟醚麻醉期间（39 - 43单位）相比，氟烷麻醉期间的脑电双频指数（BIS）值显著更高（53 - 61单位）。由于氟烷常用于儿科，我们检验了这一假设：在儿童全身麻醉期间，氟烷麻醉时的BIS值可能也高于七氟醚麻醉时的BIS值。
41例计划接受择期手术的健康、未用术前药的儿科患者，根据手术刺激情况适当滴定给予氟烷或七氟醚。
在七氟醚维持麻醉期间（n = 20），平均BIS值和呼气末浓度百分比分别为44 ± 14和2.1 ± 0.6，而氟烷组（n = 21）的相应值分别为61 ± 7和1.1 ± 0.4。
这些发现表明，儿童氟烷麻醉时的BIS值高于七氟醚麻醉时，但婴儿并非如此。
