Nielsen J, Bruhn A M
Unit for Psychiatric Research, Aalborg Psychiatric Hospital, Aalborg, Denmark.
Acta Psychiatr Scand. 2005 Sep;112(3):238-40; discussion 240. doi: 10.1111/j.1600-0447.2005.00578.x.
Neuroleptic malignant syndrome (NMS) is a rare syndrome with four main symptoms: rigidity, hyperthermia, altered mental status and autonomic instability. We report a patient with an atypical manifestation of NMS.
A single case was reported.
A patient with pneumonia developed delirium and was treated with olanzapine and developed a NMS with fluctuating hyperthermia and autonomic instability during a month. Only slight rigidity was present. Creatine kinase was not elevated. The patient was severely agitated and manic. After discontinuation of olanzapine the patient showed no psychopathology or hyperthermia.
NMS should be considered when patients treated with antipsychotics develop one or more symptoms of NMS.
抗精神病药恶性综合征（NMS）是一种罕见综合征，有四个主要症状：强直、高热、精神状态改变和自主神经功能不稳定。我们报告1例有非典型表现的NMS患者。
报告1例个案。
1例肺炎患者出现谵妄，接受奥氮平治疗，1个月内出现体温波动和自主神经功能不稳定的NMS。仅存在轻微强直。肌酸激酶未升高。患者极度烦躁和躁狂。停用奥氮平后，患者未出现精神病理学症状或高热。
使用抗精神病药治疗的患者出现NMS的一种或多种症状时，应考虑NMS。
