Tamer Cengaver, Melek Ismet M, Duman Taskin, Oksüz Hüseyin
Department of Ophthalmology, Faculty of Medicine, Mustafa Kemal University, Antakya-Hatay, Turkey.
Ophthalmology. 2005 Oct;112(10):1795. doi: 10.1016/j.ophtha.2005.04.025.
Parkinson's disease (PD) has both motor and nonmotor features. Parkinson's disease patients are prone to dry eye due to both autonomic dysfunction and motor symptoms affecting blinking. This study was conducted to investigate the changes in tear functions in PD patients.
Nonrandomized, prospective, clinical study.
Fifty-six eyes of 56 consecutive patients with PD were studied. Thirty-six eyes of age-matched non-PD patients without pathology affecting tear tests were examined as control subjects.
Modified Hoehn-Yahr (H-Y) scale, blink rate (BR), and tear tests were examined.
Modified H-Y scale, BR, dry eye assessment questionnaire, meibomian gland evaluation, tear meniscus height, tear breakup time, fluorescein stain, rose bengal stain, Schirmer's test, and phenol red thread test.
Overall tear function abnormalities were significantly more common in PD patients (P = 0.001, Mann-Whitney U test). Each test was found to be significantly disturbed in PD patients relative to controls (P<0.05, Mann-Whitney U test). Each PD patient had at least 1 abnormal test. Overall tear function abnormalities as assessed by the total abnormal test count correlated with the H-Y score (P<0.001, Spearman rho correlation). Parkinson's disease patients' mean BR (12.7+/-7.42 per minute) was significantly less than the controls' (21.8+/-7.37) (P<0.01, Student's t test). The abnormality in each tear test, except those for meibomian gland function and tear meniscus height, was significantly related to the H-Y scores (P<0.05, chi2 linear-by-linear association).
The results of this study indicate that PD is associated with disturbances in tear function. With the exception of meibomian gland disease and tear meniscus height, the tests were found to have a linear association with the H-Y scale, which may be attributed to associated dysfunctions of PD.
帕金森病（PD）具有运动和非运动特征。帕金森病患者由于自主神经功能障碍和影响眨眼的运动症状，容易出现干眼。本研究旨在调查帕金森病患者泪液功能的变化。
非随机、前瞻性临床研究。
连续纳入56例帕金森病患者的56只眼睛进行研究。选取36例年龄匹配、无影响泪液检测病变的非帕金森病患者的眼睛作为对照。
采用改良Hoehn-Yahr（H-Y）分级量表、眨眼频率（BR）及泪液检测。
改良H-Y分级量表、BR、干眼评估问卷、睑板腺评估、泪河高度、泪膜破裂时间、荧光素染色、孟加拉玫瑰红染色、泪液分泌试验及酚红棉线试验。
帕金森病患者总体泪液功能异常明显更为常见（P = 0.001，Mann-Whitney U检验）。相对于对照组，帕金森病患者的每项检测均发现有明显异常（P<0.05，Mann-Whitney U检验）。每位帕金森病患者至少有一项检测异常。通过总异常检测数评估的总体泪液功能异常与H-Y评分相关（P<0.001，Spearman等级相关）。帕金森病患者的平均BR（每分钟12.7±7.42次）明显低于对照组（21.8±7.37次）（P<0.01，Student's t检验）。除睑板腺功能和泪河高度检测外，每项泪液检测异常均与H-Y评分显著相关（P<0.05，卡方线性趋势检验）。
本研究结果表明帕金森病与泪液功能紊乱有关。除睑板腺疾病和泪河高度外，其他检测结果与H-Y分级量表呈线性相关，这可能归因于帕金森病相关的功能障碍。
