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一种铜基印度传统药物:铜灰制剂的制备与表征

Preparation and characterization of a copper based Indian traditional drug: tamra bhasma.

作者信息

Wadekar M P, Rode C V, Bendale Y N, Patil K R, Prabhune A A

机构信息

Division of Biochemical Sciences, National Chemical Laboratory, Pune 411008, India.

出版信息

J Pharm Biomed Anal. 2005 Oct 4;39(5):951-5. doi: 10.1016/j.jpba.2005.06.015. Epub 2005 Aug 10.

Abstract

The copper based Indian traditional drug 'tamra bhasma' is administered for various ailments since long. Its synthesis involves treating metallic copper with plant juices and then repeated calcination in presence of air so that the metallic state is transformed into the corresponding oxide form traditionally known as 'bhasma'. In this work, we present a systematic characterization of this traditional drug using various techniques like X-ray diffraction (XRD), scanning electron microscopy (SEM)-energy dispersive X-ray analysis (EDX), X-ray photoelectron spectroscopy (XPS), infrared spectroscopy (IR), thermogravimetry (TG) and surface area measurement. The results obtained were found to match very well with those of a standard copper oxide confirming the composition of the drug sample. In addition, some specific findings were also made which could help in interpreting the therapeutic properties of the traditional drug 'tamra bhasma'.

摘要

长期以来,基于铜的印度传统药物“铜灰制剂”被用于治疗各种疾病。其合成过程包括用植物汁液处理金属铜,然后在空气中反复煅烧,使金属态转变为传统上称为“灰制剂”的相应氧化物形式。在这项工作中,我们使用多种技术对这种传统药物进行了系统表征,如X射线衍射(XRD)、扫描电子显微镜(SEM)-能量色散X射线分析(EDX)、X射线光电子能谱(XPS)、红外光谱(IR)、热重分析(TG)和表面积测量。发现所得结果与标准氧化铜的结果非常吻合,证实了药物样品的成分。此外,还得出了一些具体发现,有助于解释传统药物“铜灰制剂”的治疗特性。

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