低密度脂蛋白受体相关蛋白1B作为铜绿假单胞菌外毒素的受体发挥作用。
LRP 1 B functions as a receptor for Pseudomonas exotoxin.
作者信息
Pastrana Diana V, Hanson Alison J, Knisely Jane, Bu Guojun, Fitzgerald David J
机构信息
Laboratory of Molecular Biology, CCR, National Cancer Institute, Bethesda, MD 20892-4263, USA.
出版信息
Biochim Biophys Acta. 2005 Sep 25;1741(3):234-9. doi: 10.1016/j.bbadis.2005.06.007.
PMID:16095885
Abstract
Pseudomonas aeruginosa is an opportunistic pathogen that produces several virulence factors, among them Pseudomonas Exotoxin A (PE). Previously, low-density lipoprotein receptor-related protein 1 (LRP 1) was shown to be the primary receptor for PE. In this report, we show that a close family member, LRP 1B, can also function as a receptor.
摘要
铜绿假单胞菌是一种能产生多种毒力因子的机会致病菌，其中包括铜绿假单胞菌外毒素A（PE）。此前，低密度脂蛋白受体相关蛋白1（LRP 1）被证明是PE的主要受体。在本报告中，我们表明其近亲家族成员LRP 1B也可作为受体发挥作用。
Zotero 插件